For the AFL cohort vs the matched control cohort, the incidences of heart failure hospitalization and all-cause mortality were significantly higher across all levels, but the incidence of ischemic stroke was only significantly higher at CHA 2DS 2-VASc scores of 5 to 9. The patients with AF were older, were more predominantly female, and had higher CHA 2DS 2-VASc scores than the patients with AFL and the control participants. Results This study comprised 188 811 patients in the AF cohort (mean age, 73.8 years 104 703 male), 6121 patients in the AFL cohort (mean age, 67.7 years 3735 male), and 24 484 patients in the matched control cohort (mean age, 67.3 years 14 940 male). Main Outcomes and Measures Ischemic stroke, heart failure hospitalization, and all-cause mortality among the AF, AFL, and matched control cohorts were analyzed using Cox proportional hazards regression. Clinical outcomes were compared after stratification by CHA 2DS 2-VASc score (possible score range, 0-9 higher scores indicate greater risk of ischemic stroke). A total of 219 416 age- and sex-matched individuals participated in the study. Follow-up and data analysis ended December 31, 2012. Objective To investigate differences in clinical outcomes among AF, AFL, and matched control cohorts.ĭesign, Setting, and Participants This nationwide cohort study analyzed data from the Taiwan National Health Insurance Research Database from January 1, 2001, through December 31, 2012. Importance Current guidelines support treating atrial fibrillation (AF) and atrial flutter (AFL) as equivalent risk factors for ischemic stroke stratified by CHA 2DS 2-VASc scores, recommending anticoagulation therapy for patients with a CHA 2DS 2-VASc score of 2 or higher, but some studies found differences in clinical outcomes. Shared Decision Making and Communication. ![]() ![]() Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.
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